Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome
نویسندگان
چکیده
منابع مشابه
Environmental Particulate Matter Induces Murine Intestinal Inflammatory Responses and Alters the Gut Microbiome
BACKGROUND Particulate matter (PM) is a key pollutant in ambient air that has been associated with negative health conditions in urban environments. The aim of this study was to examine the effects of orally administered PM on the gut microbiome and immune function under normal and inflammatory conditions. METHODS Wild-type 129/SvEv mice were gavaged with Ottawa urban PM10 (EHC-93) for 7-14 d...
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METHODS Female Wistar rats were exposed to filtered air (F) or to concentrated fine particulate matter (P) for 15 days. After mating, the rats were divided into four groups and again exposed to F or P (FF, FP, PF, PP) beginning on day 6 of pregnancy. At embryonic day 19, the placenta was collected. The placental structure, the protein and gene expression of TGFβ1, VEGF-A, and its receptor Flk-1...
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BACKGROUND Ambient particulate matter exposure has been shown to increase the risks of respiratory diseases. However, the role of the lung microbiome and the immune response to inhaled particulate matter are largely unexplored. We studied the influence of biomass fuel and motor vehicle exhaust particles on the lung microbiome and pulmonary immunologic homeostasis in rats. METHODS Fifty-seven ...
متن کاملCardiovascular remodeling in response to long-term exposure to fine particulate matter air pollution.
BACKGROUND Air pollution is a pervasive environmental health hazard that occurs over a lifetime of exposure in individuals from many industrialized societies. However, studies have focused primarily on exposure durations that correspond to only a portion of the lifespan. We therefore tested the hypothesis that exposure over a considerable portion of the lifespan would induce maladaptive cardiov...
متن کاملParticulate matter air pollution exposure: role in the development and exacerbation of chronic obstructive pulmonary disease
Due to the rapid urbanization of the world population, a better understanding of the detrimental effects of exposure to urban air pollution on chronic lung disease is necessary. Strong epidemiological evidence suggests that exposure to particulate matter (PM) air pollution causes exacerbations of pre-existing lung conditions, such as, chronic obstructive pulmonary disease (COPD) resulting in in...
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ژورنال
عنوان ژورنال: Environmental Pollution
سال: 2018
ISSN: 0269-7491
DOI: 10.1016/j.envpol.2018.04.130